RESUMO
Objective:To explore correlation among high sensitivity C reactive protein (hsCRP),inflammatory factor levels and cardiac function in patients with dilated cardiomyopathy (DCM).Methods:A total of 102 DCM patients were continu-ously collected in our hospital from Mar 2014 to Mar 2016.According to their hsCRP level at hospitalization,patients were divided into low hsCRP group (n＝51,≤3mg/L) and high hsCRP group (n＝51,＞3mg/L).Levels of hsCRP,brain na-triuretic peptide (BNP),interleukin (IL)-6,IL-1 and tumor necrosis factor (TNF)-α,left ventricular end-diastolic di-mension (LVEDd) and left ventricular ejection fraction (LVEF) were measured and compared between two groups.Corre-lation between inflammatory factors and cardiac function indexes were analyzed.Results:Compared with low hsCRP group [ (2.18 ± 0.12) mg/L],there were significant rise in LVEDd [ (58.47 ± 6.16) mm vs.(66.58 ± 9.45) mm],levels of BNP [(232.04 ± 56.07) pg/ml vs.(466.34 ± 105.12) pg/ml],IL-6 [(6.48 ± 2.48) ng/L vs.(9.38 ± 2.41) ng/L],IL-1 [(63.58 ± 6.58) ng/L vs.(67.84 ± 5.75) ng/L] and TNF-α [(74.58 ± 8.39) ng/L vs.(79.58 ± 10.71) ng/L],and significant reduction in LVEF [ (38.67 ± 6.08)% vs.(33.23 ± 5.15)%] in high hsCRP group [ (3.87 ± 1.53) mg/L],P＜0.05 or ＜0.01.Linear correlation analysis indicated that in high hsCRP patients,hsCRP level was significant positive-ly correlated with levels of IL-6,IL-1 and TNF-α ( r＝0.328～0.341,P＜0.05 all);levels of hsCRP,IL-6,IL-1 and TNF-α were significant positively correlated with BNP level,LVEDd and NYHA class (r＝0.241～0.432,P＜0.05 or ＜0.01),and significant inversely correlated with LVEF (r＝ -0.346～ -0.327,P＜0.05 all).Conclusion:High sensitivity C reactive protein level is significantly correlated with cardiac function in DCM patients.Therefore,it can be used as an important index monitoring cardiac function changes in these patients.
RESUMO
<p><b>OBJECTIVE</b>The paper is a study on the clinical symptoms and pathogeny of ectrodactyly and absence of radius side part palm and split foot malformation of some patients in one family.</p><p><b>METHODS</b>Based on the patient family investigation,a normal control group and a patient group were established. Then, polymerase chain reaction technique was used for DNA sequencing and analysis of the two groups for their exons 5-8 gene group DNA of P63 gene.</p><p><b>RESULTS</b>The medical examination found that the patients' upper bilateral limbs are short of thumbs, forefingers and middle fingers, and have radius side part palm and double lower limbs foot clefts malformation. The pathogeny research revealed that the PCR expansion pieces of the exons 5-8 of P63 are 284 bp, 259 bp, 245 bp and 259 bp respectively, and the size of the expansion piece of the patients was the same as that of the normal people group. However, a respective comparison between the DNA serial of the expansion piece of the patient and that of the normal people group and that of the P63 gene in the human gene bank showed that mutation occurs at the number 665 base pair of exon 5 of P63, namely a mutation from G to A.</p><p><b>CONCLUSION</b>The ectrodactyly, absence of radius side part palm and split foot malformation are caused by the mutation of base pair at number 665 of the exon 5 of P63.</p>